Synthesis, Spectral and Biological Evaluation of 4-Phenylthiazol-2-amine
Author -
Rovin
Dharmendra Kumar
Vikas Kumar
ABSTRACT
4-Phenylthiazol-2-amine is synthesized by 2-bromo-1-phenyletanone and thiourea. The structure of synthesized compound was also established using FTIR, UV-Vis and 1H-NMR spectral techniques. The title compound was also tested for antimicrobial activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus and fungus Candida albican, Aspergillus niger and Candida krusei.
Keywords
FTIR, NMR, Raman, UV-Visible spectroscopy, thiazole, antibacterial and antifungal activity.
References
Azam, F.; Ibn-Rajab, I. A.; Alruiad, A. A. Adenosine A. Pharmazie, 2009, 64, 771-795.
Avetisyan, A. K..; Ovsepyan, T. R.; Stepanyan, N. O.; Sapondzhyan, L. G.. Pharm. Chem. J. 1981, 15, 69-72.
Lalezari, I.; Shafiee, A.; Badaly, A.; Salimi, M. M.; Khoyi, M. A.; Abtahi, F.; Zarrindast, M. R. J. Pharm. Sci. 2006, 64, 1250-1252.
Parkanyi, C.; Yuan H.L.; Stromberg, B. H.E.; Evenzahav, A. J. Heterocycl. Chem. 1992, 29, 749- 753.
Boschelli, D.H.; Connor, D.T; Bornemeier, D.A.; Dyer, R.D.; Kennedy, J.A.; Kuipers, P.J; Okonkwo, G.C.; Schrier, D.J.; Wright. C.D. J. Med. Chem. 1993, 36, 1802-1810.
Bhattacharya, P.; Leonard, J. T.; Roy, K. Bioorg. Med. Chem. 2005, 15, 1159-1165.
Vio, L..; Mamolo, M. G.; Laneve, A. Farmaco, 1989, 44, 165-172.
Vigorita, M. G.; Ottana, R.; Monforte, F.; Maccari, R.; Trovato, A.; Monforte, M. T.; Taviano, M. F. Bioorg. Med. Chem. Lett. 2001, 11, 2791-2794.
A. El-Mekabat Chemistry of Heterocyclic Compounds 2015, 50,(12),1698-1706.
Krishnamurthy, B. , Vinaya, K., Rakshith, D. Prasanna, D. S. Rangappa, K. S., Medicinal chemistry 2013, 9 (2), 240-248.
O. V. Svaljavyn,, M. Yu. Onysko , A . V. Turov, Yu. G. Vlasenko, V. G. L endel Chemistry of Heterocyclic Compounds. 2013, 49(3) 491-495.
Abdel-Rahman B.A. ElGazzar, , Hend N. Hafez, Bioorganic & Medicinal Chemistry Letters2009, 19(13),3392–3397
Sert, Yusuf and Mahendra, M. and Shivashankar, K. and Puttaraju, K. B. and Doğan, H. and Cırak, C. and Ucun, Fatih Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2014 128.109-118.
G. Ramachandran ,S. Muthu, J. Uma Maheswari Solid State Sciences 2013, 16, 45–52.
S. Ghersetti, G. Maccagnani, A. Mangini, F. Montanari lournal of heterocyclic compound, 2009, 6(6), 859–868.
Tripathy H and Mahaputra G N, J Indian Chem Soc., 1975, 52, 168.
Vikas Kumar, Pratibha Singh, Der Pharma Chemica, 2010, 2(3),52-62